Sep 2002

TWAS Newsletter Vol. 13 No. 3 (Jul-Sep 2001)

Molecular actions of (S)-desmethylzopiclone (SEP-174559), an anxiolytic metabolite of zopiclone.

This study set out to profile the activity of (S)-desmethylzopiclone (SEP-174559) at subtypes of the gamma-aminobutyric acid type-A (GABA(A)) receptor and other neurotransmitter receptor ion channels. Recombinant receptors were expressed in human embryonic kidney 293 cells and examined functionally by patch-clamp recording with fast perfusion of agonist and drug solutions. Micromolar concentrat...

Myocardial infarction in rat eliminates regional heterogeneity of AP profiles, I(to) K(+) currents, and [Ca(2+)](i) transients.

Transient outward K(+) current density (I(to)) has been shown to vary between different regions of the normal myocardium and to be reduced in heart disease. In this study, we measured regional changes in action potential duration (APD), I(to), and intracellular Ca(2+) concentration ([Ca(2+)](i)) transients of ventricular myocytes derived from the right ventricular free wall (RVW) and interventr...

Myocardial infarction in rat eliminates regional heterogeneity of AP profiles, Ito K currents, and [Ca ]i transients

Kaprielian, Roger, Rajan Sah, Tin Nguyen, Alan D. Wickenden, and Peter H. Backx. Myocardial infarction in rat eliminates regional heterogeneity of AP profiles, Ito K currents, and [Ca2 ]i transients. Am J Physiol Heart Circ Physiol 283: H1157–H1168, 2002. First published May 2, 2002; 10.1152/ajpheart.00518.2001.—Transient outward K current density (Ito) has been shown to vary between different ...

Symbol error probability analysis of a multiuser detector for M-PSK signals based on successive cancellation

A narrow-band multiuser receiver based on successive signal detection and subtraction, is considered in this paper. The symbol error probability (SEP) for -PSK modulated signals is evaluated and analytical approximations for the SEP of the individual signals are presented and compared with results obtained from simulations. For geometrically related signal amplitudes, a constant minimum distanc...

Pii: S1388-2457(02)00335-8

Objective: To study whether sensorimotor cortical areas are involved in Essential Tremor (ET) generation. Background: It has been suggested that sensorimotor cortical areas can play a role in ET generation. Therefore, we studied median nerve somatosensory evoked potentials (SEPs) in 10 patients with definite ET. Methods: To distinguish SEP changes due to hand movements from those specifically r...